![]() It was shown that 0.001% of caffeine prevented the suppressive effect of testosterone on the cultured hair follicles. Using elegant methods, Fischer and colleagues cultivated human hair follicles from balding areas in AGA male patients and then used different concentrations of caffeine to study its stimulatory effects on the hair follicles. One of the important modes of action of caffeine is to competitively inhibit phosphodiesterase and thus increasing the level of cyclic AMP, the second messenger within the cell and for the discovery of the latter, Sutherland received the Nobel prize. Coffee is prepared from the beans after they are roasted Caffeine is a methylxanthine and about 100 mgm is present in a cup of coffee. The topic of discussion today is the world's favorite hot beverages coffee and tea and their positive effects on the bald scalp.Ĭoffee plants originated in Africa and since then have been grown in many parts of the world, Brazil being the highest producer. Clearly, therefore, alternative modalities should be sought. But only 70 to 80% of AGA patients respond to these drugs. Hitherto only two drugs have been shown to be effective in AGA viz. It is well known that the latter is due to end-organ sensitivity to dihydrotestosterone (DHT) in genetically predisposed men. Recent trichological literature suggests a nexus, which could be taken advantage of in certain types of alopecia like the androgenetic alopecia (AGA). One may wonder what the connection is between beverages and baldness. A beverage is a liquid which is specifically prepared for human consumption.
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